Formulation And Activity Test of Broiler Chicken Claw Collagen Emulgel Preparation on Burn Healing in New Zealand Rabbits

Abstrak

Burns are tissue injuries caused by contact with hot materials. Collagen from broiler chicken feet has burn healing activities formulated into emulgel preparations. Emulgel uses HPMC as a gelling agent. This study was to determine the effect of HMPC
concentration on physical quality and preparation activity on burn healing. Collagen extraction through the maceration process using acetic acid. The HPMC concentrations used were 2%, 2.5%, and 3%. Emulgel preparations are tested for physical quality and stability. Healing of burns is carried out on 5 rabbits. Emulgel was applied 2 times a day and observed wound reduction for 21 days, then statistically analyzed. The results showed that the variation in the concentration of HPMC prepared with chicken claw collagen emulgel affected physical quality, stability, and burn healing activity. Formula 1 HPMC concentration of 2% showed the best results based on physical quality, stability, and burn healing activity.