Testing The Analgesic Antipyretic Activity of Leunca (Solanum Nigrum L.) Leaf Extract on Male Mice (Muscular Muscles)

Abstrak

Pain is an unpleasant sensation that can be overcome with analgesics, while fever is an increase in body temperature that can be reduced with antipyretics. This study aims to test the activity and effective dose of antipyretic analgesic of ethanol extract of leunca leaves in male mice induced by 1% acetic acid and 10% peptone. The study used 50 Swiss Webster mice, divided into 5 groups: negative control (CMC Na 0.5%), positive control (paracetamol), and three treatment groups of leunca leaf extract (245 mg/kg, 490 mg/kg, 980 mg/kg BW). Induction was performed with 10% peptone and 1% acetic acid, followed by measurement of body temperature and pain response every 15 minutes for 90 minutes. Data were analyzed with SPSS using One Way ANOVA and Post Hoc LSD test. The results showed that the effective dose of leunca leaf extract as an analgesic and antipyretic was 490 mg/kg BW of mice.