Effectiveness Test of Ethanol Extract Fraction of Lamtoro Leaves (Leucaena Leucocephala L.) As Antidiabetes in Male White Mice (Mus Musculus)

Abstrak

Diabetes mellitus as one of the degenerative diseases is a longterm condition characterized by increased blood sugar levels and metabolic disorders. Lamtoro leaves are one of the plants that are often used as traditional medicine. This study used 30 male mice divided into 6 groups, each group consisting of 5. All groups were treated for 13 days. Day 0, day 3, day 7, and day 13 determine blood sugar levels, on day 14 mice were dissected and pancreas organs were taken which were used as histopathology preparations. Fractions of lamtoro leaf ethanol extract can effectively reduce blood sugar levels at doses of 75 mg/kg BW of water fraction, 30 mg/kg BW of ethyl acetate fraction, and 60 mg/kg BW of n-hexane fraction. Dosing the fraction of lamtoro leaf ethanol extract on the histopathology picture of the pancreas can reduce necrotic cell damage to mice.