Emulgel Formulation Aand Activity Test Of Etanol Extract Of Suji Leaves (Dracaena Angustifolia Roxb.) On Healing Of Burns In White Rabbit (Oryctolagus Cuniculus)

Abstrak

Burns are a type of injury that can cause damage and changes to various human body systems. Suji leaf ethanol extract has the fastest activity in healing burn wounds at 7% concentration. This study developed suji leaf ethanol extract into an emulgel dosage formulation by varying the concentration of HPMC. Suji leaf ethanol extract was obtained by maceration method using 70% ethanol solvent. The 7% ethanol extract of suji leaves was made into emulgel preparations in 3 formulas with varying concentrations of HPMC, namely 3%, 3.5%, and 4%. The emulgel preparations were tested for physical quality, stability and healing activity of rabbit burns for 21 days by measuring the diameter of the burns. The results showed that the variation of HPMC in suji leaf ethanol extract emulgel preparation affects viscosity, spreadability, adhesion, stability and burn healing activity. Formula I with 3% HPMC concentration variation showed the best result based on one-way ANOVA.