Antihyperglykemic Activity Test Of The Combination Activity Of Butterfly Pea Flower Extrac (Clitoria Ternatea L.) And Areca Nut Seeds (Areca Catechu L.) Extracts On Mice (Mus Musculus) Induced By Alloxa

Abstrak

Butterfly pea flowers and areca seeds are plants that can be used as antihyperglycemic agents because they contain alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids, which aid in reducing blood sugar levels. The aim of this study was to determine the antihyperglycemic effect of a combination of butterfly pea flower extract (Clitoria ternatea L.) and areca seed extract (Areca catechu L.) in male mice induced intraperitoneally with alloxan at a dose of 210 mg/kg BW. The extraction process employed maceration using 70% ethanol. The antihyperglycemic test involved 40 male mice, divided into groups: normal control, negative control (0,5% Na CMC), positive control (glibenclamide), single extract of butterfly pea flower (560 mg/kg BW), single extract of areca seed (560 mg/kg BW), combination 1, combination 2, and combination 3. Blood glucose level data were analyzed using One-Way ANOVA followed by a Post Hoc test. The results showed that both single doses and combination doses of butterfly pea flower extract (Clitoria ternatea) and areca seed extract (Areca catechu) significantly reduced blood glucose levels in mice, with no significant differences between groups.