Analgetic Potential Activity Of Ethanol Extract Of Fruit Peel (Gnetum Gnemon L.) Against Male White Mice By Writhing Test And Tail Flick Method

Abstrak

Pain is a sensory feeling that causes discomfort, and is an indicator of damage to body tissue. Ways to reduce pain, with analgesics to relieve pain. Melinjo fruit peel (Gnetum gnemon L.) contains flavonoid compounds that can inhibit the enzyme cyclooxygenase, decrease prostaglandin production and relieve pain. The extraction method of melinjo fruit peel uses maceration with 70% ethanol solvent. Analgesic activity test using tail flick and writhing test. Parameters observed were tail flick and body writhing of mice with negative control CMC-Na 0.5%, positive control (mefenamic acid and dolgesik), dose of melinjo fruit peel extract 27.46; 54.93; and 109.86 mg/kg BW. Data results were analyzed using One way ANOVA. The results showed that ethanol extract of melinjo fruit peel (Gnetum Gnemon L.) has analgesic activity in male white mice, marked by significant differences in negative control. The effective dose of melinjo fruit peel extract is 109.86 mg/kg BW