Activity Test of Areca Nut (Areca Catechu L.) and Figs (Ficus Carica L.) Combination as Antihyperglycemia in White Mice Induced by Alloxan

Abstract

Areca nut seeds and figs are plants that can be used as antihyperglycemia, because they contain flavonoid compounds, saponins, alkaloids, tannins and triterpenoids that can help the process of lowering blood sugar levels. The purpose of this study was to determine the effect of antihyperglycemia on blood sugar levels and body weight after a combination of Areca catechu L.) and figs (Ficus carica L.) in alloxane-induced male white mice. The study used 40 male white mice divided into 6 groups. mice were fasted for 8-12 hours before alloxan induction. Mice that have been selected were grouped into 8 groups, namely Group 1 (normal group), Group 2 (negative control, Na CMC 0.5%), Group 3 (positive control, glibenclamide 0.65 mg/kgBW of mice), Group 4 (single extract of areca nut 560 mg/kgBW of mice), Group 5 (single extract of figs 560 mg/kgBW of mice), and 1 combination group of areca nut and fig ethanol extracts. Before the treatment of mice first induced alloxan i.p at a dose of 210 mg/kg BWB mice. The results of blood sugar data were analyzed using One Way Anova followed by Post hoc test. The results showed a single dose of extract and combination of areca cathecu L.) and figs (Ficus carica L.) were able to reduce blood sugar levels in mice with values that are not much different from the positive control test group, while testing of the body weight of mice that were carried out showed that the combination extract was not significantly different from the positive control..