Formulation and Activity Test of Serum From Srff (Saccharomyces Cerevisiae Rice Ferment Filtrate) With 72 Hour Fermentation Time As Anti-Aging In Vivo

Abstract

 Aging is a state in which the skin begins to experience a progressive decline in function, one of which can be caused by free radicals. Free radicals damage the skin through oxidative stress with degradation of collagen and elastin. The utilization of fermentation in the anti-aging cosmetic industry is gaining popularity because it contains antioxidants that help fight free radicals that cause skin aging. This study used fermentation of 10 grams of rice with 100 ml of distilled water and Saccharomyces cerevisiae yeast for 72 hours to produce SRFF (Rice Fermented Yeast Juice). The fermentation result was processed into serum with Na CMC base (1%, 2%, and 3%) to test its anti-aging effect on the back of rabbits exposed to UV-A light. The results showed that formula 2 had anti-aging activity with collagen percentage of 116.06%, elasticity of 90.64%, and moisture of 284%. Statistically, Formula 2 was not significantly different from the positive control (p>0.05), but had a decrease in pH value on stability.