Network Phamacology of Indian Franchise (Boswellia serrata) and Turmeric Rhizome (Curcuma longa L.) as Antiinflammatory in Osteoarthritis

Abstract

Osteoarthritis is a type of arthritis caused by cartilage damage. Indian frankincense and turmeric rhizome have potential as anti- inflammatory for OA. This study identifies target proteins in the pathophysiology of OA, determines Indian frankincense and turmeric rhizome compounds that target these proteins, and analyzes the network pharmacology profile. This study used network pharmacology to analyze the chemical, with data obtained from KNApSAcK. Target proteins in OA were validated through UniProt, protein interactions were analyzed using String. Screening of active substances using PubChem, prediction of target proteins of bioactive compounds using STP, SEA, and SuperPred. Visualization of protein and compound interactions using Cytoscape. Protein NP visualization showed target proteins associated with Indian frankincense and turmeric rhizome compounds, including NFKBIA, NOS2, MAPK1, MAPK3, MAPK14, PTEN, MMP1, MMP3, MMP13, and AKT1. Active compounds such as various boswellic acids, curcumin, and quercetin form network pharmacology profiles relevant to OA target protein.