Tonicum Effect Test of Etanol Extract of Cardamom Fruit (Amomum cardamomum Willd.) on White Male Mice (Mus musculus)

Abstract

Tonic are materials valuable for fortifying the body, enhancing control and vitality, and empowering muscle cell repair. Cardamom (Amomum cardamomum Willd.) contains flavonoid and alkaloid compounds with potential tonic effects. This research aimed to investigate the tonic effects and optimal dosages of cardamom ethanol extract on male white mice. This experimental research utilized 50 male white mice (Mus musculus). Each method uses 25 male white mice divided into five groups: negative control received 0.5% Na CMC, positive control received 100 mg/kg BW caffeine, and three groups received cardamom extract at 5,6; 11,2; and 22,4 mg/kg BW. Data analysis utilized SPSS. The study employed natatory exhaustion and hanging tests to assess endurance. Results indicate cardamom extract exhibits significant tonic effects on male white mice. The optimal dosage (22,4 mg/kg BW) has the most effective potential tonic effect, with an average percentage increase in swimming duration (125%) and an average percentage increase in hanging duration (180%).