Antidiabetic Activity Test of Etanol Extract of Chayote Leaves (Sechium edule) on Alloxan Induced White Male Rats

Abstract

Chayote (Sechium edule), a member of the Cucurbitaceae family, is recognized for its potential antidiabetic properties due to the presence of secondary metabolites such as flavonoids, saponins, and tannins. This study aimed to evaluate the antidiabetic activity of ethanol extract from chayote leaves in alloxan-induced diabetic rats and assess its impact on pancreatic histopathology. Six treatment groups, each consisting of five rats, were administered alloxan intraperitoneally. Blood glucose levels were measured on days 1, 3, 7, and 14 using the GOD-PAP method. On day 15, the rats were sacrificed for analysis. The results indicated that chayote leaf extract significantly reduced blood glucose levels and improved pancreatic histopathology. Notably, a dosage of 84 mg/kg body weight was found to be the most effective, achieving glucose reduction comparable to that of glibenclamide, a standard antidiabetic medication.