Study of Drug Interactions in Inpatient Patients With Type 2 Diabetes Mellitus at Dr. Soehadi Prijonegoro Hospital Sragen in 2023

Abstract

Drug interactions can occur when a combination of 2 or more drugs is used for pharmacological therapy which causes undesirable effects. Interactions can be minor, moderate and major interactions. According to the mechanism, there can be pharmacokinetic and pharmacodynamic interactions. The aim of this research is to determine the description of the use of antidiabetic drugs, find out which drugs cause the most interactions and identify drug interactions used in Type 2 DM
patients inpatients at dr. Soehadi Prijonegoro Sragen Hospital in 2023. This research is a type of descriptive research that is non- experimental in nature using retrospective data. The samples used were Type 2 DM patients inpatients at dr. Soehadi
Prijonegoro Sragen Hospital in 2023 as many as 100 people. Next, the medical record data that was obtained was analyzed descriptively and identified the severity and mechanism of drug interactions using the Drugs.com and Stockley's Drugs Interactions websites. The results of the analysis showed that there were 89 patients who had the potential to experience drug interactions. The highest level of severity of drug interactions is moderate severity (81.1%) with pharmacodynamic mechanisms (23.6%). Drugs that have the potential to cause interactions are lansoprazole and sucralfate (9.54%).