Stability Orders of Cocystal Paracetamol and Sitric Acid are Influenced in Various Temperatures

Abstract

Cocrystal in the pharmaceutical has been developed because this is the one to solve the problem in the pharmaceutical, by varyed the amount of a single crystal form so that it changes the physicochemical properties of its single crystal component. Changes that occur include melting points, changes in hydration stability, resistance to thermal stability, changes in hygroscopic properties, solubility, and bioavailability. The crystal form is preferred because it tends to be stable, reproducible, and easily purified compared to other solid forms such as amorphous. The dissolution rate and solubility of each crystal are different so that it affects the bioavailability and arrangement of the crystal group. Paracetamol crystals is the BCS class 2 category which is difficult to dissolve in water and it will be made into a cocrystal using coformers of citric acid with different variations in temperature and time to test the crystal stability. This can be proved by detection used the FTIR to see changes in the groups in the crystal and the dissolution test and detected by UV-Vis spectro to see the stability of the crystal or cocrystal formed. By varyedtemperatures at meltingpoint or up to meltingpoint is suspected that paracetamol is not stable. The results of the dissolution test seen in the levels of paracetamol and paracetamol samples which decreased in level were in line with the increase in temperature and time variations. Data analysis using SPSS is known that there is a signification that indicates that there are differences in levels due to temperature and time variations indicating that paracetamol paracetamol and cocrystal samples are unstable.