Formulation and Activity Test of Emulgel Preparation Containing Patah Tulang Stem Extract (Euphorbia tirucalli L.) as a Wound Healer for Incisions on the Back of New Zealand Rabbits.

Abstract

The stem of the Patah Tulang plant is beneficial as an alternative treatment for cuts because it contains compounds such as sapogenin, ellagic acid, and glycosides, which help accelerate the wound healing process. Emulgel is an appropriate topical preparation for treating cuts. This study aims to determine whether the extract of the Patah Tulang stem can be formulated into an emulgel with good physical properties and to evaluate the activity and concentration of the gelling agent HPMC in wound healing.The extract of the Patah Tulang stem was obtained using the maceration method with 96% ethanol as the solvent. The extract was then formulated into an emulgel with a concentration of 10% and varying concentrations of the gelling agent HPMC (1%, 3%, and 5%). The resulting emulgel formulations were tested for their physical properties, including organoleptic tests, homogeneity, emulgel type, pH, adhesiveness, spreadability, viscosity, and stability. The wound healing activity was tested on New Zealand rabbits. Data on wound healing, physical properties, and the stability of the emulgel were analyzed statistically using SPSS.The results of the study showed that the extract of the Patah Tulang stem can be formulated into an emulgel with good physical properties and stability. The emulgel made from the extract of the Patah Tulang stem demonstrated wound healing activity, with the most effective concentration of the gelling agent HPMC being 1%.