The Tonic Effect Of Ethanol Extract Telang Leaf (Clitoria Ternatea L.) Toward White Mice (Mus musculus) Males Swiss Webster

Abstract

The telang leaf (Clitoria ternatea L.) is utilized in traditional medicine due to its active compounds, such as alkaloids, flavonoids, saponins, and essential oils. This study examined the tonic effects of ethanolic extract from telang leaf on male Swiss Webster mice and determined its effective dose. Extraction was conducted using the maceration method with 70% ethanol. The tonic activity test employed the Natatory Exhaustion and Rotarod methods, with parameters including swimming time and the duration the mice remained on the rotating rotarod. The negative control used 0.5% Na CMC, the positive control was caffeine at 13 mg/kg BW, and the telang leaf extract was tested at doses of 150, 300, and 450 mg/kg BW. Data were analyzed using the Shapiro-Wilk test, homogeneity test, One-Way ANOVA, and Tukey test. Results showed that the telang leaf extract exhibited tonic activity, with the most effective dose being 300 mg/kg BW.